Tempe has a story about its development in long trip. It began from thousand years ago. This below, you can see the tempe trip which was carried by South China traders to Indonesia, until tempe that will get an international standard in the next day. The tempe trip started from,
One of the important functional characteristics of tempe is the anti-infective effect which was noted by Van Veen (1950), Wang et al (1969), Mien K. Mahmud (1987), and Sudigbia (1990). The antibacterial activity was first found out by Wang et al. Later Mien K. Mahmud (1987) confirmed by experimental feeding trials of rabbits exposed by pathological E. coli. It was found the antibacterial activity of tempe on the cell epitheliums protecting from further cell damage.